Meningococcal Disease
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چکیده
Neisseria meningitidis N. meningitidis, or meningococcus, is an aerobic, gramnegative diplococcus, closely related to N. gonorrhoeae, and to several nonpathogenic Neisseria species, such as N. lactamica. The organism has both an inner (cytoplasmic) and outer membrane, separated by a cell wall. The outer membrane contains several protein structures that enable the bacteria to interact with the host cells as well as perform other functions.
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Immunological Aspect of Meningococcal disease: An overview in Host- Bacteria Interaction
Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...
متن کاملNeed for Optimisation of Immunisation Strategies Targeting Invasive Meningococcal Disease in the Netherlands
Invasive meningococcal disease (IMD) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. In recent years, industrialised countries have implemented vaccines targeting IMD in their National Immunisation Programmes (NIPs). In 2002, the Netherlands successfully implemented a single dose of meningococcal serogroup C conjugate vaccine at the age of 14 months a...
متن کاملEndothelial cell adhesion molecules in meningococcal disease.
BACKGROUND Endothelial damage is important in meningococcal disease. Cell adhesion molecules, including P selectin, E selectin, and intercellular cell adhesion molecule 1 (ICAM-1), are expressed by activated endothelium and then subsequently shed. METHODS ICAM-1, P selectin, and E selectin were measured on admission to hospital in children with meningococcal infections. RESULTS Concentratio...
متن کاملHigh Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine
Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of meningococcal disease (1). Administration of meningococcal vaccines is recommended for patients receiving eculizumab before beginning treatment (2,3). Sixteen cases of meningococcal disease were identified in eculizumab recipients in the Uni...
متن کاملEpiReview: Meningococcal disease in NSW, 1991-2011: trends in relation to meningococcal C vaccination.
AIM To review the epidemiology of invasive meningococcal disease in NSW for the period 1991-2011, in particular since the introduction of the meningococcal C vaccination program in 2003. METHODS We undertook a descriptive analysis of NSW notifications of invasive meningococcal disease for the period 2003-2011, and explored long-term changes in the epidemiology of invasive meningococcal diseas...
متن کاملEarly management of meningococcal disease--do attitudes of GPs influence practice?
BACKGROUND Survival from early meningococcal disease might be improved if general practitioners followed guidelines by immediately administering parenteral antibiotics (before hospital referral). METHODS Structured telephone interviews with 20 GPs who had previously treated meningococcal cases. RESULTS General practitioners knew guideline recommendations for early management of meningococca...
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